تفاعل #7141

ord-1e612694473f4566a194a7e5b40d97a4

معادلة التفاعل

NC(=O)[C@@H]1CCCCC[C@@H]1NS(=O)(=O)c1ccc(Cl)cc1
cis-2-(4-chlorobenzenesulfonylamino)-cycloheptanecarboxylic acid amide
N#Cc1ccc(CBr)cc1
4-bromomethyl-benzonitrile
→
N#Cc1ccc(CN([C@H]2CCCCC[C@H]2C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1
titled compound
المردود 3.0%
N#Cc1ccc(CN([C@H]2CCCCC[C@H]2C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1
cis-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cycloheptanecarboxylic acid amide
المردود 3.0%

المتفاعلات

NC(=O)[C@@H]1CCCCC[C@@H]1NS(=O)(=O)c1ccc(Cl)cc1
cis-2-(4-chlorobenzenesulfonylamino)-cycloheptanecarboxylic acid amide
N#Cc1ccc(CBr)cc1
4-bromomethyl-benzonitrile

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The titled compound (6.4 mg) was prepared in 3% yield from cis-2-(4-chlorobenzenesulfonylamino)-cycloheptanecarboxylic acid amide (150 mg, 0.45 mmol) and 4-bromomethyl-benzonitrile according to the N-alkylation procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.84 (m, 3 H), 7.69 (m, 4 H), 7.50 (d, 1 H, J=8.0 Hz), 7.31 (s br, 1 H), 6.65 (s br, 1 H), 4.60 (AB2,2 H,Δv=16,Jab=96 Hz), 3.93 (m, 1 H), 2.79 (m, 1 H), 2.24 (m, 1 H), 1.72 (m, 2 H), 1.31 (m, 7 H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07084178B2uspto-grants-2006_08