تفاعل #7139

ord-386f48eba40548c182cc938b1a8dd1e7

معادلة التفاعل

NC(=O)[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(Cl)cc1
trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide
N#Cc1ccc(CBr)cc1
4-bromomethyl-benzonitrile
→
N#Cc1ccc(CN([C@@H]2CCCC[C@H]2C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1
titled compound
المردود 43.0%
N#Cc1ccc(CN([C@@H]2CCCC[C@H]2C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1
trans-2-[(4- Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide
المردود 43.0%

المتفاعلات

NC(=O)[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(Cl)cc1
trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide
N#Cc1ccc(CBr)cc1
4-bromomethyl-benzonitrile

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The titled compound was prepared in 43% yield from trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 4-bromomethyl-benzonitrile according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.71(m, 4 H), 7.53 (m, 4 H), 7.29 (s, 1 H), 6.76 (s, 1 H), 4.44 (AB2,2 H,Δv=16,Jab=84 Hz), 3.96 (m, 1 H), 1.80 (m, 1 H), 1.57 (m, 3 H), 1.17 (m, 5 H); MS m/e 432.01 (M+H)+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07084178B2uspto-grants-2006_08