تفاعل #713853

معادلة التفاعل

N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N′-methylpyrimidine-4,6-diamine

(2-chloro-6-methylpyrimidin-4-yl)-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]amine

methylamine

→

title compound

المردود 33.0%

N4-[2-(2,6-Dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-6,N2-dimethylpyrimidine-2,4-diamine

المردود 33.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىwere reacted

الإجراء التجريبي

Following the procedure described for N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N′-methylpyrimidine-4,6-diamine, (2-chloro-6-methylpyrimidin-4-yl)-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]amine and methylamine were reacted to afford the title compound as a yellow solid (24 mg, 33% yield). 1H NMR (400 MHz, DMSO-d6): δ 9.88 (s, 1H), 9.16 (s, 1H), 7.94 (d, J=6.4 Hz, 1H), 7.81-7.80 (m, 2H), 7.70 (dd, J=9.0, 7.3 Hz, 1H), 7.65 (s, 1H), 7.15 (dd, J=6.4, 1.0 Hz, 1H), 2.82 (d, J=4.8 Hz, 3H), 2.25 (s, 3H). LCMS (Method B): RT=2.90 min, m/z: 400 [M+H+].

المصدر