تفاعل #71341

معادلة التفاعل

Formaldehyde

diethyl amine

2-nitro-imidazole

→

title compound

Diethyl-(2-nitro-1H-imidazol-4-ylmethyl)-amine

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting mixture was heated
2. 2
   درجة الحرارةto reflux for 18 h
3. 3
   تركيزconcentrated

الإجراء التجريبي

Formaldehyde (36% in H2O, 1.0 mL, 13.3 mmol, 1.5 equiv) and diethyl amine (0.92 mL, 8.8 mmol) were added sequentially to a suspension of 2-nitro-imidazole (1 g, 8.8 mmol) in EtOH (20 mL). The resulting mixture was heated to reflux for 18 h, allowed to cool to rt, and concentrated. Trituration of the residue in Et2O afforded an impure sample of the title compound which was used without further purification.

المصدر