تفاعل #71339

معادلة التفاعل

2-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

→

title compound

المردود 96.0%

1-(2-Trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-ylamine

المردود 96.0%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through a pad of celite
2. 2
   تركيزconcentrated

الإجراء التجريبي

A suspension of 2-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole (Step 14.3) (1.84 g, 7.57 mmol) and palladium on carbon (200 mg) in MeOH (30 mL) was stirred for 40 min at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 1.55 g of the title compound: ESI-MS: 214.1 [M+H]+; tR=3.26 min (System 1).

المصدر