تفاعل #712143

معادلة التفاعل

6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid

1-oxa-7-azaspiro[4.4]nonane

TBTU

DIEA

→

title compound

[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridin-2-yl]-(1-oxa-7-aza-spiro[4.4]non-7-yl)-methanone

ظروف التفاعل

الإجراء التجريبي

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with 1-oxa-7-azaspiro[4.4]nonane (176-12-5) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=394.5 [MH+].

المصدر