تفاعل #7120

معادلة التفاعل

cis-2-Aminocyclohexanecarboxylic acid methyl ester

ammonium hydroxide

→

cis-2-aminocyclohexanecarboxylic acid amide

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction was concentrated to dryness in vacuo
2. 2
   أخرىazeotroped with toluene (50 mL)
3. 3
   أخرىThe crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification

الإجراء التجريبي

cis-2-Aminocyclohexanecarboxylic acid methyl ester (2.20 g, 14.0 mmol) was treated with aqueous ammonium hydroxide (40 mL) in toluene (40 mL) and stirred vigorously at room temperature for 16 h. The reaction was concentrated to dryness in vacuo and azeotroped with toluene (50 mL). The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (2 H, s br), 7.67 (s, 1 H), 7.25 (s, 1 H), 1.87 (m, 2 H), 1.60 (m, 4 H), 1.41 (m, 4 H).

المصدر