تفاعل #71077

معادلة التفاعل

2-[2-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-4-ylmethyl]-4-nitro-2H-[1,2,3]triazole

NH4Cl

N2

→

title compound

2-[2-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-4-ylmethyl]-2H-[1,2,3]triazol-4-ylamine

المذيبات

EtOH

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered while hot and
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   workup.ADDITIONCH2Cl2 (10 mL) was added
4. 4
   استخلاصThe aq. layer was extracted with CH2Cl2 (2×10 mL)
5. 5
   تجفيفextracts were dried over MgSO4
6. 6
   ترشيحfiltered
7. 7
   أخرىthe solvents were removed under reduced pressure

الإجراء التجريبي

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a mixture of 2-[2-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-4-ylmethyl]-4-nitro-2H-[1,2,3]triazole (86 mg, 0.29 mmol), iron powder (49 mg, 0.87 mmol) and NH4Cl (78 mg, 1.45 mmol) in a mixture of EtOH (1.0 mL) and water (0.5 mL) was stirred at 75° C. for 60 min. The reaction mixture was filtered while hot and concentrated under reduced pressure. CH2Cl2 (10 mL) was added followed by 1N NaOH (10 mL). The aq. layer was extracted with CH2Cl2 (2×10 mL) and the combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give the title compound as an oil. LC-MS-conditions 02: tR=0.68 min; [M+H]+=268.25.

المصدر