تفاعل #710536

معادلة التفاعل

Monomethyl fumarate

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

3-Morpholin-4-yl-propan-1-ol

→

title compound

Methyl 3-morpholin-4-ylpropyl (2E)but-2-ene-1,4-dioate

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the completion of the reaction

الإجراء التجريبي

Monomethyl fumarate (MMF) was reacted with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDAC) (1.2 eq) in dichloromethane (DCM) at ca. 0° C. 3-Morpholin-4-yl-propan-1-ol (1 eq) and 4-N,N-dimethylaminopyridine (DMAP) (catalytic amount) were added to the activated carboxylic acid. After the completion of the reaction, followed by the work-up of the reaction mixture, the title compound was isolated as a viscous-oil.

المصدر