تفاعل #710526

معادلة التفاعل

Compound I

2-(1,3-benzodioxol-5-yl)-2-methyl propanal

NH2OH

pyridine

→

Compound J

المردود 96.0%

2-(1,3-benzodioxol-5-yl)-2-methyl propanal oxime

المردود 96.0%

المذيبات

ethanol

HCl

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was evaporated to dryness
2. 2
   workup.ADDITIONadded 10 mL of ethyl acetate
3. 3
   غسيلThe organic layer was washed with distilled water
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated
7. 7
   أخرىThe crude reaction mixture
8. 8
   أخرىwas purified over silica gel column

الإجراء التجريبي

To a solution of Compound I (511 mg, 2.66 mmol) in ethanol (1 mL), HCl.NH2OH (277 mg, 4.00 mmol) and pyridine (2.2 mL, 26.58 mmol) were added and it was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated to dryness and added 10 mL of ethyl acetate. The organic layer was washed with distilled water, dried over anhydrous sodium sulfate, filtered and evaporated. The crude reaction mixture was purified over silica gel column using 5:1 petroleum ether-ethyl acetate as solvent to afford Compound J (528 mg, 96%) as a white foam.

المصدر