تفاعل #710503

ord-09beeee2505841458329c4dc2d85ed28

معادلة التفاعل

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

المتفاعلات

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

الكواشف

لا شيء

المذيبات

O
water
O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىreaction
  2. 2
    أخرىfor the reaction
  3. 3
    أخرىCarbon dioxide is evaporated rapidly
  4. 4
    أخرىwater is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    أخرىThe product is then dried
  7. 7
    أخرىcrushed to fine particles
  8. 8
    أخرىto produce an active composition suitable for formulation into the pharmacological formulations of this invention

الإجراء التجريبي

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09301935B2uspto-grants-2016_04