تفاعل #710489

معادلة التفاعل

N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene}-2-(trifluoromethyl)benzamide

acetic acid

→

desired product

المردود 24.0%

2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1-{[2-(trifluoromethyl)benzoyl]amino}ethyl acetate

المردود 24.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated to 90° C. for one day
2. 2
   workup.WAITleft at room temperature for four days
3. 3
   تركيزAfter concentration in vacuo
4. 4
   أخرىthe crude product was purified by chromatography on silica gel

الإجراء التجريبي

0.16 g of N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene}-2-(trifluoromethyl)benzamide (Int-6) were diluted in 2 mL of acetic acid. The reaction mixture was stirred for two days at room temperature and then heated to 90° C. for one day and left at room temperature for four days. After concentration in vacuo, the crude product was purified by chromatography on silica gel to yield 0.045 g (24%) of desired product 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1-{[2-(trifluoromethyl)benzoyl]amino}ethyl acetate (Ia-112), [M+1]=455.

المصدر