تفاعل #710481

معادلة التفاعل

2-chloro-5-chloromethyl pyridine

2-aminopyrimidine

→

1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride

المردود 34.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىwas returned to room temperature
2. 2
   workup.DISTILLATIONto distill off DMF under reduced pressure
3. 3
   workup.ADDITIONDiethyl ether was added
4. 4
   أخرىthus crystallization
5. 5
   أخرىwas occurred on the wall surface of an eggplant flask
6. 6
   أخرىDiethyl ether was removed by decantation
7. 7
   أخرىdried well

الإجراء التجريبي

300 mg (1.86 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 6 ml of anhydrous DMF, 118 mg (1.24 mmol) of 2-aminopyrimidine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the reaction solution was returned to room temperature to distill off DMF under reduced pressure. Diethyl ether was added thereto, and thus crystallization was occurred on the wall surface of an eggplant flask. Diethyl ether was removed by decantation and dried well to obtain 1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride. Amount obtained 107 mg (yield 34%)

المصدر