تفاعل #710476

معادلة التفاعل

2-chloro-5-chloromethyl pyridine

2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide

potassium carbonate

→

2-chloro-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2-difluoroacetamide

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىsynthesized by the aforementioned method
2. 2
   درجة الحرارةthe resulting mixture was heated
3. 3
   درجة الحرارةrefluxed for 1 hours
4. 4
   أخرىwas returned to room temperature
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   workup.ADDITIONDiethyl ether was added
7. 7
   أخرىto precipitate a solid
8. 8
   أخرىthus the solid was collected
9. 9
   أخرىdried
10. 10
    أخرىto obtain the subject material
11. 11
    أخرىAmount obtained 49 mg (yield 45%)

الإجراء التجريبي

53 mg (0.33 mmol) of 2-chloro-5-chloromethyl pyridine dissolved in 6 ml of anhydrous acetonitrile was added to 68 mg (0.33 mmol) of the 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the aforementioned method, and subsequently, 50 mg (0.36 mmol) of potassium carbonate was added thereto and the resulting mixture was heated and refluxed for 1 hours. After the reaction was completed, the reaction solution was returned to room temperature and then concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected and dried to obtain the subject material. Amount obtained 49 mg (yield 45%).

المصدر