تفاعل #710475

معادلة التفاعل

2-aminopyridine

EDC-HCl

chlorodifluoroacetic acid

→

2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide

المردود 24.0%

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water and 1% hydrochloric acid
2. 2
   تجفيفdried over anhydrous magnesium sulfate

الإجراء التجريبي

200 mg (2.13 mmol) of 2-aminopyridine was dissolved in 5 ml of dichloromethane, 491 mg (2.55 mmol) of EDC-HCl, 311 mg (2.55 mmol) of DMAP and 187 μl (2.23 mmol, 290 mg) of chlorodifluoroacetic acid were added thereto in sequence, and the resulting mixture was stirred overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed with water and 1% hydrochloric acid, and then dried over anhydrous magnesium sulfate to obtain 105 mg (yield 24%) of 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide.

المصدر