تفاعل #710470

معادلة التفاعل

2-bromo-5-methylpyridine

N-bromosuccinimide

→

2-bromo-5-bromomethylpyridine

المردود 20.0%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting mixture was heated
2. 2
   درجة الحرارةrefluxed for 19 hours
3. 3
   أخرىwas returned to room temperature
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   أخرىpurified by silica gel column chromatography (hexane:ethyl acetate=19:1)

الإجراء التجريبي

500 mg (2.92 mmol) of 2-bromo-5-methylpyridine was dissolved in 15 ml of carbon tetrachloride, 623 mg (3.50 mmol) of N-bromosuccinimide and 10 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed for 19 hours. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 143 mg (yield 20%) of 2-bromo-5-bromomethylpyridine.

المصدر