تفاعل #7098

معادلة التفاعل

oxime

3-fluoro-5-bromobenzaldehyde oxime

→

3-fluoro-5-bromobenzonitrile

المردود 89.3%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   درجة الحرارةunder reflux
3. 3
   أخرىthe mixture was evaporated
4. 4
   غسيلwashed with sulfuric acid (1N), water, brine
5. 5
   تجفيفdried (MgSO4)
6. 6
   أخرىevaporated

الإجراء التجريبي

The above oxime (3.76 g, 17.24 mmol) and copper (II) acetate (370 mg) were dissolved in acetonitrile (100 cm3) under nitrogen and heated under reflux. After 5 h, the mixture was evaporated, the residue taken into EtOAc, washed with sulfuric acid (1N), water, brine, dried (MgSO4) and evaporated to give 3-fluoro-5-bromobenzonitrile (3.08 g, 15.39 mmol, 89%) which was used without further purification.

المصدر