تفاعل #709618

معادلة التفاعل

p-nitrobenzyl (1R,5R,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-oxo-1-carbapenam-3-carboxylate

2-(4-methyl-3-oxopiperazin-1-yl)-2-iminoethylmercaptan hydrochloride

→

title compound

المردود 9.1%

(1R,5S,6S)-2-[2-(4-Methyl-3-oxopiperazin-1-yl)-2-iminoethylthio]-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid

المردود 9.1%

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter hydrogenation and filtration over "Celite" (Trade Mark)
2. 2
   ترشيحfilter aid
3. 3
   استخلاصthe filtrate was extracted twice with 20 ml portions of diethyl ether
4. 4
   تركيزThe aqueous phase was concentrated by evaporation under reduced pressure
5. 5
   أخرىthe residue was purified by chromatography through a Lobar column (Merck "LiChloprep RP-8", size B, two columns)
6. 6
   غسيلeluted with 2% aqueous methanol

الإجراء التجريبي

The procedure of Example 1(3) was repeated, except that 100 mg of p-nitrobenzyl (1R,5R,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-oxo-1-carbapenam-3-carboxylate and 90 mg of 2-(4-methyl-3-oxopiperazin-1-yl)-2-iminoethylmercaptan hydrochloride were used. After hydrogenation and filtration over "Celite" (Trade Mark) filter aid, the filtrate was extracted twice with 20 ml portions of diethyl ether. The aqueous phase was concentrated by evaporation under reduced pressure, and the residue was purified by chromatography through a Lobar column (Merck "LiChloprep RP-8", size B, two columns), eluted with 2% aqueous methanol, to give 10 mg of the title compound.

المصدر