تفاعل #70941

معادلة التفاعل

hydrochloric acid

3,4-bis-benzyloxy-5-nitro-benzonitrile

sodium azide

ammonium chloride

→

5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling to room temperature
2. 2
   workup.ADDITIONthe reaction mixture was poured onto water (30 mL)
3. 3
   أخرىThe resulting precipitate was collected
4. 4
   غسيلwashed with water
5. 5
   أخرىdried

الإجراء التجريبي

A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole, 0.53 g (87%).

المصدر