تفاعل #70839
ord-613a553cbe3646d580f88062a12ccac2
معادلة التفاعل
الكواشف
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ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىthe two phases were separated
- 2استخلاصThe aqueous phase was extracted with CHCl3
- 3تجفيفThe organic phase was dried over Na2SO4
- 4تركيزconcentrated to dryness
الإجراء التجريبي
To a solution of methyl piperidine-4-carboxylate (10.00 g, 6.4 mmol) and triethylamine (10.32 g, 10.2 mmol) in CHCl3 (100 mL), benzyl bromide (14.69 g, 8.6 mmol) was added under argon atmosphere while cooling with a water and ice bath. The mixture was stirred at room temperature overnight. CHCl3 and water were added and the two phases were separated. The aqueous phase was extracted with CHCl3. The organic phase was dried over Na2SO4 and concentrated to dryness, to afford 13.80 g of the desired compound as an orange solid (yield: 88%).