تفاعل #70736

معادلة التفاعل

3-(aminomethyl)-4-cyclohexyl-6-methyl-2(1H)-pyridinone

Intermediate 3

3-(aminomethyl)-4-cyclohexyl-6-methyl-2(1H)-pyridinone

4-cyclopropyl-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

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title compound

3-(Aminomethyl)-4-cyclopropyl-6-methyl-2(1H)-pyridinone

ظروف التفاعل

المعالجة

1. 1
   أخرىObtained

الإجراء التجريبي

The title compound was prepared in the same manner as described for 3-(aminomethyl)-4-cyclohexyl-6-methyl-2(1H)-pyridinone (Intermediate 3) using 4-cyclopropyl-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (5 g, 28.7 mmol). Obtained: 0.50 g (10%). LCMS E-S (M+H)=179.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.76-11.78 (br s, 1H), 7.82-7.92 (br s, 3H), 5.61 (s, 1H), 3.94-3.99 (m, 2H), 2.11 (s, 3H), 1.98-2.05 (m, 1H), 0.95-1.01 (m, 2H), 0.74-0.79 (m, 2H).

المصدر