تفاعل #706588

معادلة التفاعل

4-nitrophenyl isothiocyanate

4,4'-diaminodiphenyl methane

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titled compound

N,N"-(methylenedi-4,1-phenylene)bis[N'-(4-nitrophenyl)thiourea]

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent is removed by vacuum evaporation
2. 2
   أخرىThe solid obtained
3. 3
   غسيلis washed with n-hexane (3×25 mL) and isopropanol (3×10 mL)
4. 4
   workup.DISSOLUTIONNext, the solid is dissolved in ethyl acetate (50 mL)
5. 5
   غسيلwashed with water (3×25 mL)
6. 6
   تجفيفThe organic phase is dried with sodium sulfate
7. 7
   أخرىThe solvent is removed by vacuum evaporation

الإجراء التجريبي

A solution of 4-nitrophenyl isothiocyanate (0.45 g, 2.52 mmol) in dioxane (25 mL) is slowly added, with magnetic stirring, to a solution of 4,4'-diaminodiphenyl methane (0.25 g, 1.26 mmol) in dioxane (10 mL). After 24 hours of stirring at room temperature, the solvent is removed by vacuum evaporation. The solid obtained is washed with n-hexane (3×25 mL) and isopropanol (3×10 mL). Next, the solid is dissolved in ethyl acetate (50 mL) and washed with water (3×25 mL). The organic phase is dried with sodium sulfate. The solvent is removed by vacuum evaporation. The titled compound is obtained as a yellow powder. mp: 115° C.

المصدر