تفاعل #70609

ord-f361ca36333847c5b8676d7e90545240

معادلة التفاعل

NS(=O)(=O)c1ccc(CNc2nc(NC3(C(F)(F)F)CCCC3)c3nc(-c4ccc(F)cc4)ccc3n2)cc1

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopentylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide

NS(=O)(=O)c1ccc(CNc2nc(NC3(C(F)(F)F)CCCCC3)c3nc(-c4ccc(F)cc4)ccc3n2)cc1

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclohexylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide

→

NS(=O)(=O)c1ccc(CNc2nc(NC3(C(F)(F)F)CCC3)c3nc(-c4ccc(F)cc4)ccc3n2)cc1

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclobutylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide

المتفاعلات

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopentylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclohexylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية

See reaction.notes.procedure_details.

الإجراء التجريبي

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopentylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclohexylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08536187B2uspto-grants-2013_09