تفاعل #7044

معادلة التفاعل

1,1-di-indol-3-yl-butane

benzylchloride

→

product

المردود 78.0%

1,1-di-(N-benzyl-indol-3-yl)-butane

المردود 78.0%

المذيبات

H2O CHCl3

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture thus obtained
2. 2
   workup.STIRRINGthe ultrasonic stirring
3. 3
   أخرىthe chloroform phase was separated
4. 4
   غسيلwashed with a small amount of water
5. 5
   أخرىdried on Na2SO4
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated to dryness
8. 8
   أخرىThe end product was isolated
9. 9
   أخرىpurified chromatographically on silica gel
10. 10
    غسيلeluting with hexane

الإجراء التجريبي

ST 1385 1,1-di-indol-3-yl-butane, 290 mg (1 mmol), was thoroughly mixed and blended with potassium tertbutylate (280 mg) and tetrabutylammonium bromide (20 mg). The mixture thus obtained was held under ultrasonic stirring at ambient temperature. 640 mg (5 mmol) of benzylchloride at 0° C. were then added and the ultrasonic stirring was continued for 2 hours at room temperature. At the end of this period, the reaction mixture was treated with H2O/CHCl3; the chloroform phase was separated, washed with a small amount of water, dried on Na2SO4, filtered and concentrated to dryness. The end product was isolated and purified chromatographically on silica gel, eluting with hexane:ethyl ether 95:5.351 mg of product were obtained with a 78% yield.

المصدر