تفاعل #7039

معادلة التفاعل

7-azaindole

butyraldehyde

→

1,1-di-(7-azaindol-3-yl)-butane

المردود 15.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىST 1436 was prepared
2. 2
   أخرىThe reaction
3. 3
   درجة الحرارةhowever, was heated
4. 4
   درجة الحرارةunder reflux for 48 hours
5. 5
   أخرىThe end product was isolated
6. 6
   أخرىpurified chromatographically on a silica column
7. 7
   غسيلeluting with a CH2Cl2

الإجراء التجريبي

ST 1436 was prepared as described in example 2/2 from 7-azaindole and butyraldehyde. The reaction, however, was heated under reflux for 48 hours. The end product was isolated and purified chromatographically on a silica column eluting with a CH2Cl2:CH3COCH3 gradient ranging from 9:1 to 4:6. Yield 15%.

المصدر