تفاعل #703571

معادلة التفاعل

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

methane sulfonyl chloride

triethylamine

→

2-cyano-2-(2,4-dichlorophenyl)decyl methane sulfonate

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added dropwise at 10° C.
2. 2
   درجة الحرارةheated on a steam bath for another 30 minutes
3. 3
   أخرىThe precipitate formed
4. 4
   ترشيحis filtered
5. 5
   غسيلthe filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
6. 6
   تجفيفdried over magnesium sulfate
7. 7
   أخرىThe solvent is evaporated
8. 8
   أخرىto give 41.3g

الإجراء التجريبي

To a mixture of 2-cyano-2-(2,4-dichlorophenyl)decan-1-ol (40g., 0.12 mole) and methane sulfonyl chloride (15.3g., 0.13 mole) in 2 liters of benzene is added dropwise at 10° C., 14.8g., (0.14 mole) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 41.3g. of product, which is identified by nmr.

المصدر