تفاعل #70346

معادلة التفاعل

residue

tert-butyl 2-(3′-chloro-2,4′-bipyridin-5-ylamino)-5-methylbenzoate

→

expected product

المردود 62.0%

2-(3′-Chloro-2,4′-bipyridin-5-ylamino)-5-methylbenzoic acid

المردود 62.0%

المذيبات

trifluoroacetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   أخرىthe solid residue was triturated with an isopropyl ether/hexane mixture
3. 3
   ترشيحThe solid was filtered off

الإجراء التجريبي

The solid residue obtained in step A was dissolved in 3 ml of trifluoroacetic acid and stirred for 1 hour at room temperature. The solvent was evaporated and the solid residue was triturated with an isopropyl ether/hexane mixture. The solid was filtered off affording 0.16 g (yield 62%) of the expected product.

المصدر