تفاعل #70342

معادلة التفاعل

5-methyl-2-(quinolin-3-ylamino)benzoic acid

→

desired compound

المردود 79.0%

5-methyl-2-(5,6,7,8-tetrahydroquinolin-3-ylamino)benzoic acid

المردود 79.0%

المذيبات

TFA

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter that the reaction mixture was filtered
2. 2
   تركيزconcentrated
3. 3
   workup.DISSOLUTIONredissolved in water
4. 4
   workup.ADDITIONThe pH was adjusted to 4-5 by addition of 2N NaOH
5. 5
   أخرىa solid was formed
6. 6
   أخرىThis yellow solid formed

الإجراء التجريبي

A solution of 5-methyl-2-(quinolin-3-ylamino)benzoic acid (Example 16) (1.08 mmol, 0.30 g) in TFA (2.5 ml) was hydrogenated under pressure (58 psi) with PtO2 (0.11 mmol, 0.028 g) as catalyst until all starting material disappeared. After that the reaction mixture was filtered, concentrated and redissolved in water. The pH was adjusted to 4-5 by addition of 2N NaOH and a solid was formed. This yellow solid formed was the desired compound (0.249 mg, 79% of yield).

المصدر