تفاعل #70334

معادلة التفاعل

methyl 2-(6-(benzyloxy)-5-phenylpyridin-3-ylamino)-5-cyclopropylbenzoate

→

5-Cyclopropyl-2-(6-hydroxy-5-phenylpyridin-3-ylamino)benzoic acid

المذيبات

TFA

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   workup.ADDITION2N aqueous NaOH were added
3. 3
   أخرىThe solvent was removed
4. 4
   استخلاصextracted with CHCl3
5. 5
   أخرىThe crude mixture was purified by ionic exchange through a SCX cartridge
6. 6
   أخرىaffording
7. 7
   أخرى0.060 g (50% of yield)

الإجراء التجريبي

A solution of methyl 2-(6-(benzyloxy)-5-phenylpyridin-3-ylamino)-5-cyclopropylbenzoate (0.34 mmol, 0.155 g) in TFA (1.3 ml) was stirred at 45° C. for 30 minutes. The solvent was removed under reduced pressure. The crude mixture was solved in ethanol (2 ml), 2N aqueous NaOH were added and stirred at room temperature for 16 hours. The solvent was removed and the crude was neutralised with 2N aqueous HCl and extracted with CHCl3. The crude mixture was purified by ionic exchange through a SCX cartridge affording 0.060 g (50% of yield).

المصدر