تفاعل #70331

معادلة التفاعل

tert-butyl 2-(6-cyclopropyl-5-methylpyridin-3-ylamino)-5-methylbenzoate

→

expected product

2-(6-Cyclopropyl-5-methylpyridin-3-ylamino)-5-methylbenzoic acid

المذيبات

TFA

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude mixture was purified by reverse phase chromatography
2. 2
   أخرىaffording

الإجراء التجريبي

A solution of tert-butyl 2-(6-cyclopropyl-5-methylpyridin-3-ylamino)-5-methylbenzoate (1.52 mmol, 0.514 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.150 g (35% of yield) of the expected product.

المصدر