تفاعل #70317

معادلة التفاعل

2-(tert-butoxycarbonylamino)-5-(trifluoromethyl)benzoic acid

H2SO4

ethanol

→

expected product

المردود 41.0%

Ethyl 2-amino-5-(trifluoromethyl)benzoate

المردود 41.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   workup.ADDITIONwater was added
3. 3
   استخلاصextracted with CHCl3
4. 4
   أخرىThe crude mixture was purified by chromatography over SiO2 eluting with DCM/MeOH mixtures

الإجراء التجريبي

A mixture of 2-(tert-butoxycarbonylamino)-5-(trifluoromethyl)benzoic acid (7.21 mmol, 2.2 g), H2SO4 (36 mmol, 1.92 ml) in ethanol (25 ml) was stirred at 100° C. for 16 hours. The solvent was evaporated, water was added, pH was taken to 6 and extracted with CHCl3. The crude mixture was purified by chromatography over SiO2 eluting with DCM/MeOH mixtures and affording 0.69 g (yield 41%) of the expected product.

المصدر