تفاعل #7030

معادلة التفاعل

Water

methyl iodide

potassium carbonate

5-Biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol

→

3-biphenyl-4-yl-4-(2-fluorophenyl)-5-methylsulfanyl-4H-1,2,4-triazole

المردود 72.5%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   استخلاصfollowed by extraction with chloroform
2. 2
   غسيلThe organic layer was washed with saturated aqueous saline
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   أخرىAfter the solvent was evaporated under reduced pressure
5. 5
   أخرىthe resulting solid was recrystallized from a mixture solvent of acetonitrile and ethyl acetate

الإجراء التجريبي

5-Biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol (2.7 g) was dissolved in acetonitrile (50 ml), followed by addition of methyl iodide (0.967 ml) and potassium carbonate (1.07 g), and stirred at ambient temperature for 3 hours. Water was added to the reaction solution, followed by extraction with chloroform. The organic layer was washed with saturated aqueous saline and dried over anhydrous magnesium sulfate. After the solvent was evaporated under reduced pressure, the resulting solid was recrystallized from a mixture solvent of acetonitrile and ethyl acetate, to afford the entitled compound 3-biphenyl-4-yl-4-(2-fluorophenyl)-5-methylsulfanyl-4H-1,2,4-triazole as pale yellow crystal (2.03 g, 72%). The physico-chemical values are as follows.

المصدر