تفاعل #70290

معادلة التفاعل

2-(benzyloxy)-5-nitro-3-phenylpyridine

→

expected product

المردود 81.2%

6-(Benzyloxy)-5-phenylpyridin-3-amine

المردود 81.2%

المذيبات

ethanol

HCl

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe crude was filtered through Celite
2. 2
   غسيلwashed with ethanol
3. 3
   أخرىThe solvent was evaporated
4. 4
   workup.ADDITIONethyl acetate was added
5. 5
   غسيلwas washed with NaHCO3 4% aqueous solution, water and brine
6. 6
   أخرىThe crude was purified by chromatography
7. 7
   غسيلeluting with DCM/MeOH

الإجراء التجريبي

To a solution of 2-(benzyloxy)-5-nitro-3-phenylpyridine (0.98 mmol, 0.3 g) in 10 mL of ethanol, 0.1 mL of HCl 35% and 0.27 g of Fe was added. The mixture was heated at 90° C. for 4 hours. The crude was filtered through Celite and washed with ethanol. The solvent was evaporated, ethyl acetate was added and was washed with NaHCO3 4% aqueous solution, water and brine. The crude was purified by chromatography eluting with DCM/MeOH mixtures affording 0.22 g (yield 79%) of expected product.

المصدر