تفاعل #7029

معادلة التفاعل

1-(Biphenyl-4-carbonyl)-4-(2-fluorophenyl)thiosemicarbazide

hydrochloric acid

→

5-biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol

المردود 97.4%

المذيبات

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed
2. 2
   درجة الحرارةunder heating for 3 hours
3. 3
   ترشيحThe precipitate was filtered
4. 4
   غسيلwashed with water

الإجراء التجريبي

1-(Biphenyl-4-carbonyl)-4-(2-fluorophenyl)thiosemicarbazide (12.1 g) was suspended in aqueous 2 mol/liter sodium hydroxide solution (300 ml), and refluxed under heating for 3 hours. After the reaction solution was cooled to ambient temperature, the solution was neutralized under ice cooling with conc. hydrochloric acid. The precipitate was filtered and washed with water, to afford 5-biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol as pale yellow solid (11.2 g, 97%). The physico-chemical values are as follows.

المصدر