تفاعل #70276

معادلة التفاعل

methyl 2-amino-5-bromobenzoate

cyclopropylboronic acid

K3PO4

P(Cy)3

→

expected product

المردود 88.3%

Methyl 2-amino-5-cyclopropylbenzoate

المردود 88.3%

المذيبات

toluene

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through celite
2. 2
   أخرىthe organic phase was separated
3. 3
   أخرىevaporated

الإجراء التجريبي

In a schlenck tube, a mixture of methyl 2-amino-5-bromobenzoate (43.47 mmol, 10 g), cyclopropylboronic acid (112.92 mmol, 9.700 g), K3PO4 (144.16 mmol, 30.6 g), Pd(AcO)2 (3.47 mmol, 0.780 g), P(Cy)3 (7.85 mmol, 2.2 g) in toluene (170 ml) and water (10 ml) was heated for 2 hours at 100° C., under nitrogen atmosphere. The reaction mixture was filtered through celite and the organic phase was separated and evaporated affording 7.34 g (yield 77%) of the expected product.

المصدر