تفاعل #702313

معادلة التفاعل

1-diethylamino-2,3-epoxypropane

cyanamide monosodium

→

2-Amino-5-diethylaminomethyl-2-oxazoline

المردود 68.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added
2. 2
   أخرىthe methanol is evaporated
3. 3
   ترشيحby filtering
4. 4
   غسيلThe ether phase is washed twice with 2 cc of water
5. 5
   أخرىthen dried on Na2SO4
6. 6
   أخرىafter decanting
7. 7
   أخرىThe ether is evaporated under low pressure
8. 8
   أخرىThe resulting oily phase crystallizes
9. 9
   غسيلafter washing with boiling heptane

الإجراء التجريبي

0.2 Mole of the 1-diethylamino-2,3-epoxypropane thus prepared is added, drop by drop, to 12.8 g of the cyanamide monosodium derivative dissolved in 200 cc of anhydrous methanol with vigorous stirring. After 15 hours of stirring at ambient temperature, the methanol is evaporated and the residue picked up with 300 cc of ether. The precipitate is eliminated by filtering. The ether phase is washed twice with 2 cc of water then dried on Na2SO4 after decanting. The ether is evaporated under low pressure. The resulting oily phase crystallizes after washing with boiling heptane. 2-Amino-5-diethylaminomethyl-2-oxazoline is thus obtained with a yield of 68%. It is purified by recrystallization in heptane.

المصدر