تفاعل #701884

معادلة التفاعل

thionyl chloride

3,5-dimethyl-1,2,4-triazole

formaldehyde

1-chloromethyl-3,5-dimethyl-1,2,4-triazole

1,4-dihydroxy-N-[γ-(2,4-di-tert-amylphenoxy)propyl]-2-naphthamide

sodium ethoxide

→

1-Hydroxymethyl-3,5-dimethyl-1,2,4-triazole

المذيبات

DMF

ظروف التفاعل

الإجراء التجريبي

1-Hydroxymethyl-3,5-dimethyl-1,2,4-triazole which was prepared from 3,5-dimethyl-1,2,4-triazole and formaldehyde was reacted with 1.5 to 5 times on a molar basis of thionyl chloride to prepare 1-chloromethyl-3,5-dimethyl-1,2,4-triazole. This was reacted with an equimolar amount of 1,4-dihydroxy-N-[γ-(2,4-di-tert-amylphenoxy)propyl]-2-naphthamide in DMF in the presence of 1.5 to 3 times on a molar basis of sodium ethoxide to obtain Coupler (36).

المصدر