تفاعل #701170

معادلة التفاعل

4,5-diphenyl-2-iodooxazole

n-Butyl-isobutyramide

n-butyl lithium

water

→

2-(N-Butyl-2-methylpropanamido)-4,5-Diphenyloxazole

المذيبات

THF

THF

hexane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGThe mixture was stirred for 6 hours at room temperature
3. 3
   أخرىThe solvent was removed in vacuo
4. 4
   استخلاصthe residue extracted with diethyl ether

الإجراء التجريبي

n-Butyl-isobutyramide (2.06 g, 0.0144 m) in dry THF (20 ml) was stirred at room temperature during the dropwise addition of a 1.445 M solution of n-butyl lithium in hexane (10.0 ml., 0.01445 m). After the addition, the mixture was stirred for 5 minutes, and then 4,5-diphenyl-2-iodooxazole (Chemical Abstracts 65 7159h) (5.0 g, 0.0144 m) in dry THF (20 ml) was added dropwise. The mixture was stirred for 6 hours at room temperature and then hydrolysed with water. The solvent was removed in vacuo and the residue extracted with diethyl ether.

المصدر