تفاعل #70038

ord-08d7ac3e2aaf4b138490cb7faa4c7e3b

معادلة التفاعل

[C-]#[N+]CC(C)(C)OC(=O)OC
1-isocyano-2-methylpropan-2-yl methyl carbonate
Nc1ccc2[nH]cnc2c1
1H-benzo[d]imidazol-5-amine
O=Cc1ccc(C2CCC(=O)CC2)cc1
4-(4-oxocyclohexyl)benzaldehyde
CC(C)(C)[O-].[Na+]
sodium tert.-butoxide
CC(C)(C)OC(=O)CC(=O)[O-]
mono-tert-butyl malonate
O=C1CCC(c2ccc(C3C(=O)CC(=O)N3c3ccc4[nH]cnc4c3)cc2)CC1
1-(1H-Benzo[d]imidazol-5-yl)-5-(4-(4-oxocyclohexyl)phenyl)-pyrrolidine-2,4-dione

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىThe compound was synthesized

الإجراء التجريبي

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.803 g, 6.04 mmol), 4-(4-oxocyclohexyl)benzaldehyde (1.5 g, 6.04 mmol), mono-tert-butyl malonate (0.97 g, 6.04 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (0.95 g, 6.04 mmol) and sodium tert.-butoxide (0.60 mg, 5.35 mmol) according to method 5.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08530670B2uspto-grants-2013_09