تفاعل #70006

معادلة التفاعل

(E)-3-(3′-Adamantan-1-yl-4′-cyanomethoxybiphenyl-4-yl)-acrylic acid methyl ester

LiOH.H2O

→

(E)-3-(3′-Adamantan-1-yl-4′-cyanomethoxybiphenyl-4-yl)-acrylic acid

المذيبات

THF H2O

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solution thus obtained
2. 2
   أخرىTHF was removed under reduced pressure
3. 3
   ترشيحwas filtered (216 mg, 93%)

الإجراء التجريبي

(E)-3-(3′-Adamantan-1-yl-4′-cyanomethoxybiphenyl-4-yl)-acrylic acid methyl ester (240 mg, 0.56 mmol) was added to a solution of LiOH.H2O (117 mg, 2.8 mmol) in 24 ml of THF:H2O 1:1. The solution thus obtained was kept under stirring at RT overnight. THF was removed under reduced pressure and the resulting aqueous layer acidified with 1N HCl to allow the formation of the title compound as a white precipitate that was filtered (216 mg, 93%).

المصدر