تفاعل #69981

معادلة التفاعل

4-(4-bromophenyl)piperidin-4-ol

triethylamine

methanesulphonyl chloride

→

4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلIt is washed with water
2. 2
   تجفيفThe organic phase is dried over sodium sulphate
3. 3
   أخرىevaporated under reduced pressure
4. 4
   أخرىThe crude product obtained
5. 5
   أخرىis chromatographed on silica gel, elution

الإجراء التجريبي

1 g of 4-(4-bromophenyl)piperidin-4-ol is placed in 20 ml of dichloromethane. 0.65 ml of triethylamine and then 0.33 ml of methanesulphonyl chloride are added. The reaction mixture is stirred at ambient temperature for 2 h. It is washed with water and then with a saturated aqueous sodium chloride solution. The organic phase is dried over sodium sulphate and then evaporated under reduced pressure. The crude product obtained is chromatographed on silica gel, elution being carried out with a dichloromethane/methanol (99/1) solvent mixture. 1.1 g of 4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol are obtained.

المصدر