تفاعل #699572

معادلة التفاعل

DL-norvaline

ethanol

sulphuric acid

→

2-aminopentanoic acid ethyl ester

المردود 82.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture refluxed for eight days
2. 2
   أخرىA clear solution was formed, from which
3. 3
   درجة الحرارةafter cooling
4. 4
   أخرىethanol was removed by distillation
5. 5
   workup.DISSOLUTIONThe residue was redissolved in 200 ml of distilled water
6. 6
   workup.ADDITIONby adding potassium carbonate
7. 7
   استخلاصExtraction
8. 8
   غسيلthe mixture washed once with 50 ml of a saturated sodium chloride solution
9. 9
   تجفيفdried over sodium sulphate
10. 10
    أخرىOnce the solvent had been removed by distillation

الإجراء التجريبي

A suspension of 11.72 g of DL-norvaline in 90 ml of ethanol was combined with 3.6 ml of concentrated sulphuric acid and the mixture refluxed for eight days. A clear solution was formed, from which, after cooling, ethanol was removed by distillation. The residue was redissolved in 200 ml of distilled water and the pH adjusted to a value of between 10 and 12 by adding potassium carbonate. Extraction was then performed three times with 50 ml portions of ethyl acetate, the mixture washed once with 50 ml of a saturated sodium chloride solution and dried over sodium sulphate. Once the solvent had been removed by distillation, 11.93 g of 2-aminopentanoic acid ethyl ester (82% of th.) were obtained in the form of a yellowish oil.

المصدر