تفاعل #698994

ord-138f9668ca614035b421f58e8bd0638e

المذيبات

ظروف التفاعل

درجة الحرارة
75°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىaffording high
  2. 2
    أخرىyields of oxidized products

الإجراء التجريبي

A solution containing 1M cyclohexane, 0.625M 2,6-dichloropyridine N-oxide and 0.10 mM [Ru(TPFPP)(NO)(H2O)](SbF6) in 1 ml d6 -benzene was heated for eight hours in a sealed tube at 75° C. affording high yields of oxidized products. A combined yield of 93% and 1500 catalytic turnovers were obtained of two products, cyclohexanone and cyclohexanol (mole ratio 4:1). In CD2Cl2 the same reaction conditions proceeded to give 5600 turnovers to generate cyclohexanone and cyclohexanol (8:1) in a combined 98% yield in twelve hours. 2,6-dichloropyridine-N-oxide was unable to hydroxylate cyclohexane by heat alone as shown by a control experiment, proving that the ruthenium complex must be present to effect reaction. ##STR8##

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06002026uspto-grants-1999_12