تفاعل #697972

معادلة التفاعل

4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide

hydrochloric acid

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4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide hydrochloride

المردود 89.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe water was evaporated completely
2. 2
   أخرىthe residue was recrystallized from ethanol/diethyl ether

الإجراء التجريبي

11.5 g (0.0373 mol) of 4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide were treated with 11.5 ml of 25 percent aqueous hydrochloric acid and stirred at 0° C. for 1 hour. The water was evaporated completely and the residue was recrystallized from ethanol/diethyl ether. There were obtained 11.8 g (89%) of 4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide hydrochloride (1:1.8) as pale yellow crystals; m.p. 175-250° C. (dec.).

المصدر