تفاعل #6976
ord-4666dd45d7d6434b83112ed5ee7716cf
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىThe above reaction mixture
- 2غسيلwashed with 10% NaHCO3 (3×5 mL), and 10% LiCl (5 mL)
- 3تجفيفThe organic layer was dried over Na2SO4
- 4تركيزconcentrated
- 5أخرىthe residue was purified by preparative HPLC
الإجراء التجريبي
To a solution of 4-fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzoic acid (35 mg, 0.10 mmol) in DMF (1 mL) at RT, cyclopropylmethyl amine (14 mg 0.20 mmol) was added followed by the addition of BOP reagent (53 mg, 0.12 mmol). The above reaction mixture was stirred for 2 h, diluted with EtOAc (10 mL), washed with 10% NaHCO3 (3×5 mL), and 10% LiCl (5 mL). The organic layer was dried over Na2SO4, concentrated and the residue was purified by preparative HPLC to give the title compound as a off-white solid (33 mg, 83%). (M+H)+=398.