تفاعل #697373

معادلة التفاعل

acetonitrile

pentafluoropyridine

t-butylamine

→

title compound

المردود 71.4%

4-(t-butylamino)-2,3,5,6-tetrafluoropyridine

المردود 71.4%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلthe mixture was washed twice with 800 ml of distilled water
2. 2
   تجفيفThe chloroform layer was dried over anhydrous magnesium sulfate
3. 3
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To 100 ml of acetonitrile was added 24.5 g of pentafluoropyridine, and the mixture was stirred in an ice bath simultaneously with the dropwise addition of 30 g of t-butylamine. When the mixture warmed to room temperature, 150 ml of chloroform was added, and the mixture was washed twice with 800 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 23 g of the title compound as a pale yellow oil.

المصدر