تفاعل #69686

معادلة التفاعل

3-hydroxyphthalic anhydride

4-methoxybenzylamine

acetic acid

→

title compound

المردود 81.1%

Hydroxy-2-(4-methoxy-benzyl)-isoindole-1,3-dione

المردود 81.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   ترشيحThe white solid was collected by filtration
3. 3
   غسيلwashed well with water
4. 4
   أخرىdried

الإجراء التجريبي

A mixture of 3-hydroxyphthalic anhydride (543 mg, 3.31 mmol), 4-methoxybenzylamine (0.43 mL, 3.31 mmol) and acetic acid (3 mL) was heated at 100° C. for 4 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (760 mg, 81%). 1H NMR (DMSO-d6) 11.03 (1H, s), 7.61 (1H, dd), 7.28 (1H, d), 7.23-7.19 (3H, m), 6.89-6.86 (2H, m), 4.63 (2H, s), 3.71 (3H, s). MS: [M−H+] 282.

المصدر