تفاعل #696703

معادلة التفاعل

4-Vinylbenzyl chloride

Ethyl acetoacetate

sodium ethoxide

→

ethyl 2-(4-vinylbenzyl)-3-oxobutanoate

المردود 95.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas cooled in an ice-water bath
2. 2
   درجة الحرارةThe mixture was refluxed for 16 hours
3. 3
   ترشيحthe resulting slurry was filtered
4. 4
   أخرىto remove any salt
5. 5
   أخرىthe solution collected
6. 6
   أخرىThe solvent was removed under reduced pressure

الإجراء التجريبي

Ethyl acetoacetate (27.61 g, 0.21 mol) was dissolved in ethanol (100 ml) which was cooled in an ice-water bath, and sodium ethoxide (15.59 g, 0.22 mol) was added. 4-Vinylbenzyl chloride (33.92 g, 0.2 mole) was added. The mixture was refluxed for 16 hours, then the resulting slurry was filtered to remove any salt, and the solution collected. The solvent was removed under reduced pressure to give ethyl 2-(4-vinylbenzyl)-3-oxobutanoate in the form of a light red liquid (49 g) in 95% yield.

المصدر