تفاعل #69632

معادلة التفاعل

ammonium chloride

ethanol

2,3-dichloro-6-nitrobenzaldehyde

sodium borohydride

→

2,3-dichloro-6-nitrobenzyl alcohol

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe solution was extracted three times with EtOAc
2. 2
   تجفيفThe combined organic layers were dried (MgSO4)
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a solution of 2,3-dichloro-6-nitrobenzaldehyde (7.62 g, 34.9 mmol) in tetrahydrofuran (75 mL) was added sodium borohydride (1.31 g, 34.9 mmol) followed by ethanol (1.75 mL), and the mixture was stirred for 1.5 hours. Saturated aqueous ammonium chloride (75 mL) was added, and the solution was extracted three times with EtOAc. The combined organic layers were dried (MgSO4) and then concentrated to give 2,3-dichloro-6-nitrobenzyl alcohol, as an oil which crystallised, 7.62 g (98%).

المصدر