تفاعل #6960

معادلة التفاعل

2,4-difluoro-5-nitrobenzoic acid

→

2,4-difluoro-5-aminobenzoic acid

المردود 97.6%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was degassed
2. 2
   ترشيحfiltered
3. 3
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

To a solution of 2,4-difluoro-5-nitrobenzoic acid (0.998 g, 4.91 mmol) in ethanol (50 mL) was added 10% palladium on charcoal (107 mg) and the mixture was hydrogenated at 30 psi. After 2 h, the mixture was degassed, filtered and the filtrate was concentrated in vacuo to afford 2,4-difluoro-5-aminobenzoic acid (0.83 g, 97%) as tan solid. LC/MS (ESI); (M-H)−=172.

المصدر